EFFECTS OF ASYMPTOMATIC INFECTIONS ON THE SPATIAL

ABSTRACT

Asymptomatic infection and transmission are common for quite a few directly or indirectly transmitted diseases such as COVID-19, cholera, and Zika fever. In this paper, we propose a susceptible-infective-asymptomatic-recovered patch model to address the influence of asymptomatic infections on the spatial spread of infectious diseases. The multipatch basic reproduction number 72.0 of the model is defined and shown to be a threshold quantity for disease eradication and persistence. Namely, the disease disappears if 72.0 < 1 whereas it spreads otherwise. The monotonicity of 72.0 with respect to the dispersal rates of the symptomatic and asymptomatic populations is investigated. In particular, for the two-patch case, 72.0 is either strictly decreasing or strictly increasing or constant in terms of dispersal rates. However, nonmonotonic dependence can occur with movement between three or more patches. The asymptotic profiles of the endemic equilibrium (when it exists) as one or all dispersal rates approach zero or infinity are studied. Interestingly, an increase in infectious dispersal may decrease 72.0 but increase the number of nonsusceptible individuals. Analytical and numerical results confirm that ignoring asymptomatic carriers not only significantly underestimates the infection risk but also impairs the efficacy of travel restrictions.