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The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2.
Ivashchenko, Andrey A; Zagribelnyy, Bogdan A; Ivanenkov, Yan A; Ivashchenko, Ilya A; Karapetian, Ruben N; Kravchenko, Dmitry V; Savchuk, Nikolay P; Yakubova, Elena V; Ivachtchenko, Alexandre V.
  • Ivashchenko AA; ChemDiv Inc., San Diego, CA 92130, USA.
  • Zagribelnyy BA; ChemDiv Inc., San Diego, CA 92130, USA.
  • Ivanenkov YA; ChemDiv Inc., San Diego, CA 92130, USA.
  • Ivashchenko IA; ChemDiv Inc., San Diego, CA 92130, USA.
  • Karapetian RN; ChemDiv Inc., San Diego, CA 92130, USA.
  • Kravchenko DV; ChemDiv Inc., San Diego, CA 92130, USA.
  • Savchuk NP; Viriom Inc., San Diego, CA 92130, USA.
  • Yakubova EV; Viriom Inc., San Diego, CA 92130, USA.
  • Ivachtchenko AV; ChemDiv Inc., San Diego, CA 92130, USA.
Molecules ; 27(15)2022 Aug 05.
Article in English | MEDLINE | ID: covidwho-1979319
ABSTRACT
The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Animals / Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27154975

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Animals / Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27154975