INTERMEMBRANE OLIGOMERIZATION OF SARS-COV-2 M-PROTEIN: POSSIBLE ROLE IN VIRAL BUDDING
Bulletin of Russian State Medical University
; - (3):38-41, 2022.
Article
in English
| Web of Science | ID: covidwho-1979882
ABSTRACT
Despite the extensive research spurred by the catastrophic effects of COVID-19 pandemic. precise molecular mechanisms of some stages in SARS-CoV-2 life cycle remain elusive. One of such stages is the detachment of viral particles during budding. Using confocal fluorescence microscopy, we observed formation of specific structures by endoplasmic reticulum in human cells expressing SARS-CoV-2 M-protein, implicating oligomerization of M-protein across parallel membranes. In our opinion, such intermembrane oligomerization may provide a driving forts for pinching off the viral particles during SARS-CoV-2 budding.
Full text:
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Bulletin of Russian State Medical University
Year:
2022
Document Type:
Article
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