To Determine the Effect of Diabetes Mellitus on the Clinical Course and Outcome of COVID-19 at Jinnah Hospital, Lahore, Pakistan
Pakistan Journal of Medical and Health Sciences
; 16(7):41-43, 2022.
Article
in English
| EMBASE | ID: covidwho-1980031
ABSTRACT
Background:
Diabetes is a common disease known to cause morbidity and mortality. Individuals with diabetes are at greater risk of complications from coronavirus and have recently gains attention of researchers and practitioners.Aim:
To assess the effect of diabetes mellitus on clinical course and outcome of coronavirus infection. Studydesign:
Prospective cohort study Place and duration of study Coronavirus Disease High Dependency Unit Jinnah Hospital, Lahore from 01-01-2021 to03-04-2021.Methodology:
Three hundred and seventy six patients of either genders and age range of 15-75 years were enrolled. They were divided into diabetic or non-diabetic groups. The various attributes such as demographic data, medical history, COVID-19 exposure history, symptoms and signs, laboratory findings, chest radiograph findings, the treatment measures and complications of diabetes and in hospital outcome were compared for both the groups.Result:
Statistically different from each other in terms of oxygen requirement, lymphocyte %, neutrophil to lymphocyte ratio (P=0.026), alanine aminotransferase (P=0.038), C-reactive protein (P=0.048), ferritin (P=0.031), lactic acid dehydrogenase (LDH) (P=0.011), Ddimer (P=0.024), Quick sequential organ failure assessment score (qSOFA score) (P=0.001) and Chest X-ray (P=0.049), blood sugar random (P=0.000), treatment during hospital stay (P=0.000), insulin dose increase (P=0.000), complications during hospital stay (P=0.042) and shifting to the intensive care unit (P=0.002).Conclusion:
Diabetic coronavirus patients have poorer prognosis due to higher risk of severe pneumonia and related complications including mortality than their non-diabetic counterparts.
adolescent; article; cohort analysis; comorbidity; complication; controlled study; coronavirus disease 2019; demographics; diabetes mellitus; diabetic ketoacidosis; female; gender; glucose blood level; high dependency unit; hospitalization; human; intensive care unit; lymphocyte; major clinical study; male; medical history; mortality; neutrophil; neutrophil lymphocyte ratio; outcome assessment; Pakistan; pneumonia; prognosis; prospective study; quick Sequential Organ Failure Assessment Score; thorax radiography; alanine aminotransferase; C reactive protein; cytokine; endogenous compound; ferritin; insulin; lactate dehydrogenase; oxygen
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Pakistan Journal of Medical and Health Sciences
Year:
2022
Document Type:
Article
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