EFFECTIVENESS OF ZINC AND ROS ON TESTOSTERONE HORMONE LEVELS FOR RECOVERING COVID-19 PATIENTS

ABSTRACT

COVID-19 (coronavirus disease 2019), cause severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) across all age groups, it’s a positive-sense single-stranded RNA virus, and a member of the Betacoronavirus genus taxonomically (Jiang et al, 2020). Given the importance roles of zinc in combating oxidative damage and viral infections, Zinc also has confirmed roles in both male and female reproduction. The possible depletion of zinc with the oxidative events of COVID-19 is especially relevant to the fertility of affected couples (Sethuram et al, 2021). The aim of study is to determine the relation between zinc value and oxidative stress level represented by ROS (Reactive Oxygen Species) and testosterone level among the recovered COVID-19 patients in reproductive age. 120 men chosen from Center of Medical City, Health Center of 9 Nisan, Poisoning Consultation Center and Kamal AL-Samarrai Hospital, 70 recovered males from COVID-19 within a period of 6 months after the last negative PCR nasopharyngeal swab and 50 as control group (uninfected COVID-19) from the Medical staff and the relatives, during the period from December/ 2020 to February / 2021. Testosterone hormone level were measured for each male, level of COVID-19 anti-nucleocapsid IgG was estimated and designed as selection criteria for recovery from COVID-19. Pearson’s correlation coefficient and A stepwise method in linear regression statistic test was applied to detect the association of testosterone hormone level with zinc and ROS. The mean and standard deviation level of studied parameters are differ between cases of current studying;recovering COVID-19 males and control group then compared with normal value of each test. The levels of COVID-19 anti-nucleocapsid IgG increase among recovering males compared with control group, statistically highly-significant (P-value = 0.00), as well oxidative stress among cases recovered from Covid-19 compared with level of control are statistically highly-significant (P-value= 0.00), while levels of zinc are decreased among cases studied compared with control group, this differences was highly-significant (P-value = 0.00). In conclusion, the most factors affecting Testosterone hormone level identified in the study are Zinc, ROS