Oridonin Inhibits SARS‐CoV‐2 by Targeting Its 3C‐Like Protease
Small science
; 2(6), 2022.
Article
in English
| EuropePMC | ID: covidwho-1981330
ABSTRACT
Oridonin Inhibits SARS‐CoV‐2 Oridonin, a natural product extracted from Rabdosia rubescens, possesses a wide range of pharmacological properties, including anti‐inflammatory, anti‐cancer, anti‐microbial, neuroprotection, immunoregulation, etc. In article number 2100124, Baisen Zhong, Litao Sun, and co‐workers demonstrate that Oridonin targets the SARS‐CoV‐2 3CL protease by covalently binding to cysteine145 in its active pocket to exert an anti‐SARS‐CoV‐2 effect, which provides a novel candidate for the treatment of COVID‐19. © 2022 WILEY‐VCH GmbH
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Collection:
Databases of international organizations
Database:
EuropePMC
Language:
English
Journal:
Small science
Year:
2022
Document Type:
Article
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