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Machine learning to predict in-hospital mortality among patients with severe obesity: Proof of concept study.
Soffer, Shelly; Zimlichman, Eyal; Levin, Matthew A; Zebrowski, Alexis M; Glicksberg, Benjamin S; Freeman, Robert; Reich, David L; Klang, Eyal.
  • Soffer S; Internal Medicine B Assuta Medical Center Ashdod Israel.
  • Zimlichman E; Ben-Gurion University of the Negev Be'er Sheva Israel.
  • Levin MA; Hospital Management Sheba Medical Center Tel Hashomer Israel.
  • Zebrowski AM; Sackler Medical School Tel Aviv University Tel Aviv Israel.
  • Glicksberg BS; Sheba Talpiot Medical Leadership Program Tel Hashomer Israel.
  • Freeman R; Department of Population Health Science and Policy Institute for Healthcare Delivery Science Icahn School of Medicine at Mount Sinai New York New York USA.
  • Reich DL; Department of Anesthesiology, Perioperative and Pain Medicine Icahn School of Medicine at Mount Sinai New York New York USA.
  • Klang E; Department of Emergency Medicine Icahn School of Medicine at Mount Sinai New York New York USA.
Obes Sci Pract ; 8(4): 474-482, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1981949
ABSTRACT

Objectives:

Hospitalized patients with severe obesity require adapted hospital management. The aim of this study was to evaluate a machine learning model to predict in-hospital mortality among this population.

Methods:

Data of unselected consecutive emergency department admissions of hospitalized patients with severe obesity (BMI ≥ 40 kg/m2) was analyzed. Data was retrieved from five hospitals from the Mount Sinai health system, New York. The study time frame was between January 2011 and December 2019. Data was used to train a gradient-boosting machine learning model to identify in-hospital mortality. The model was trained and evaluated based on the data from four hospitals and externally validated on held-out data from the fifth hospital.

Results:

A total of 14,078 hospital admissions of inpatients with severe obesity were included. The in-hospital mortality rate was 297/14,078 (2.1%). In univariate analysis, albumin (area under the curve [AUC] = 0.77), blood urea nitrogen (AUC = 0.76), acuity level (AUC = 0.73), lactate (AUC = 0.72), and chief complaint (AUC = 0.72) were the best single predictors. For Youden's index, the model had a sensitivity of 0.77 (95% CI 0.67-0.86) with a false positive rate of 19.

Conclusion:

A machine learning model trained on clinical measures provides proof of concept performance in predicting mortality in patients with severe obesity. This implies that such models may help to adopt specific decision support tools for this population.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Obes Sci Pract Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Obes Sci Pract Year: 2022 Document Type: Article