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The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults.
Oliveto, Giuseppe; Scagnolari, Carolina; Frasca, Federica; Sorrentino, Leonardo; Matera, Luigi; Nenna, Raffaella; Viscido, Agnese; Scordio, Mirko; Petrarca, Laura; Maria Zicari, Anna; Gentilini, Elio; D'Ettorre, Gabriella; Ceccarelli, Giancarlo; Midulla, Fabio; Antonelli, Guido; Pierangeli, Alessandra.
  • Oliveto G; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy. Electronic address: giuseppe.oliveto@uniroma1.it.
  • Scagnolari C; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Frasca F; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Sorrentino L; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Matera L; Department of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
  • Nenna R; Department of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
  • Viscido A; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Scordio M; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Petrarca L; Department of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
  • Maria Zicari A; Department of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
  • Gentilini E; Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
  • D'Ettorre G; Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
  • Ceccarelli G; Department of Public Health and Infectious Diseases, "Sapienza" University, Rome, Italy.
  • Midulla F; Department of Maternal, Infantile and Urological Sciences, "Sapienza" University, Rome, Italy.
  • Antonelli G; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
  • Pierangeli A; Virology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Cytokine ; 158: 155997, 2022 10.
Article in English | MEDLINE | ID: covidwho-1982909
ABSTRACT
The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Topics: Variants Limits: Adult / Humans Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Topics: Variants Limits: Adult / Humans Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article