The association of airborne particulate matter and benzo[a]pyrene with the clinical course of COVID-19 in patients hospitalized in Poland.
Environ Pollut
; 306: 119469, 2022 Aug 01.
Article
in English
| MEDLINE | ID: covidwho-1982985
ABSTRACT
Air pollution can adversely affect the immune response and increase the severity of the viral disease. The present study aimed to explore the relationship between symptomatology, clinical course, and inflammation markers of adult patients with coronavirus disease 2019 (COVID-19) hospitalized in Poland (n = 4432) and air pollution levels, i.e., mean 24 h and max 24 h level of benzo(a)pyrene (B(a)P) and particulate matter <10 µm (PM10) and <2.5 µm (PM2.5) during a week before their hospitalization. Exposures to PM2.5 and B(a)P exceeding the limits were associated with higher odds of early respiratory symptoms of COVID-19 and hyperinflammatory state interleukin-6 > 100 pg/mL, procalcitonin >0.25 ng/mL, and white blood cells count >11 × 103/mL. Except for the mean 24 h PM10 level, the exceedance of other air pollution parameters was associated with increased odds for oxygen saturation <90%. Exposure to elevated PM2.5 and B(a)P levels increased the odds of oxygen therapy and death. This study evidences that worse air quality is related to increased severity of COVID-19 and worse outcome in hospitalized patients. Mitigating air pollution shall be an integral part of measures undertaken to decrease the disease burden during a pandemic of viral respiratory illness.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Air Pollutants
/
Air Pollution
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Environ Pollut
Journal subject:
Environmental Health
Year:
2022
Document Type:
Article
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