Function and regulation of ULK1: From physiology to pathology.
Gene
; 840: 146772, 2022 Oct 05.
Article
in English
| MEDLINE | ID: covidwho-1983092
ABSTRACT
The expression of ULK1, a core protein of autophagy, is closely related to autophagic activity. Numerous studies have shown that pathological abnormal expression of ULK1 is associated with various human diseases such as neurological disorders, infections, cardiovascular diseases, liver diseases and cancers. In addition, new advances in the regulation of ULK1 have been identified. Furthermore, targeting ULK1 as a therapeutic strategy for diseases is gaining attention as new corresponding activators or inhibitors are being developed. In this review, we describe the structure and regulation of ULK1 as well as the current targeted activators and inhibitors. Moreover, we highlight the pathological disorders of ULK1 expression and its critical role in human diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autophagy
/
Intracellular Signaling Peptides and Proteins
/
Autophagy-Related Protein-1 Homolog
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Gene
Year:
2022
Document Type:
Article
Affiliation country:
J.gene.2022.146772
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