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Function and regulation of ULK1: From physiology to pathology.
Rong, Ze; Zheng, Kaifeng; Chen, Jun; Jin, Xiaofeng.
  • Rong Z; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China.
  • Zheng K; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China.
  • Chen J; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China. Electronic address: cjcj992@163.c
  • Jin X; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China; Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China. Electronic address: jinxiaofeng@n
Gene ; 840: 146772, 2022 Oct 05.
Article in English | MEDLINE | ID: covidwho-1983092
ABSTRACT
The expression of ULK1, a core protein of autophagy, is closely related to autophagic activity. Numerous studies have shown that pathological abnormal expression of ULK1 is associated with various human diseases such as neurological disorders, infections, cardiovascular diseases, liver diseases and cancers. In addition, new advances in the regulation of ULK1 have been identified. Furthermore, targeting ULK1 as a therapeutic strategy for diseases is gaining attention as new corresponding activators or inhibitors are being developed. In this review, we describe the structure and regulation of ULK1 as well as the current targeted activators and inhibitors. Moreover, we highlight the pathological disorders of ULK1 expression and its critical role in human diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Intracellular Signaling Peptides and Proteins / Autophagy-Related Protein-1 Homolog / Neoplasms Limits: Humans Language: English Journal: Gene Year: 2022 Document Type: Article Affiliation country: J.gene.2022.146772

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Intracellular Signaling Peptides and Proteins / Autophagy-Related Protein-1 Homolog / Neoplasms Limits: Humans Language: English Journal: Gene Year: 2022 Document Type: Article Affiliation country: J.gene.2022.146772