Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis.
Int J Cardiol Heart Vasc
; 43: 101108, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-1983173
ABSTRACT
Concerns have been raised recently about takotsubo cardiomyopathy (TCM) after receiving COVID-19 vaccines, particularly the messenger RNA (mRNA) vaccines. The goal of this study was to compile case reports to provide a comprehensive overview of takotsubo cardiomyopathy (TCM) associated with COVID-19 vaccines. A systematic literature search was conducted in PubMed, Scopus, Embase, Web of Science, and Google Scholar between 2020 and June 1, 2022. The study included individuals who developed cardiac takotsubo cardiomyopathy from receiving COVID-19 vaccinations. Ten studies, including 10 cases, participated in the current systematic review. The mean age was 61.8â¯years; 90â¯% were female, while 10â¯% were male. 80â¯% of the patients received the mRNA COVID-19 vaccine, while 20â¯% received other types. In addition, takotsubo cardiomyopathy (TCM) occurred in 50â¯% of patients receiving the first dose and another 40â¯% after the second dose of COVID-19 vaccines. Moreover, the mean number of days to the onset of symptoms was 2.62â¯days. All cases had an elevated troponin test and abnormal ECG findings. The left ventricular ejection fraction (LVEF) was lower than 50â¯% in 90â¯% of patients. In terms of the average length of hospital stay, 50â¯% stayed for 10.2â¯days, and all cases recovered from their symptoms. In conclusion, takotsubo (stress) cardiomyopathy (TCM) complications associated with COVID-19 vaccination are rare but can be life-threatening. Chest pain should be considered an alarming symptom, especially in those who have received the first and second doses of the COVID-19 vaccine.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Reviews
/
Systematic review/Meta Analysis
Topics:
Vaccines
Language:
English
Journal:
Int J Cardiol Heart Vasc
Year:
2022
Document Type:
Article
Affiliation country:
J.ijcha.2022.101108
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