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Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO).
Mylonakis, Eleftherios; Lutaakome, Joseph; Jain, Mamta K; Rogers, Angela J; Moltó, José; Benet, Susana; Mourad, Ahmad; Files, D Clark; Mugerwa, Henry; Kityo, Cissy; Kiweewa, Francis; Nalubega, Mary Grace; Kitonsa, Jonathan; Nabenkema, Evelyn; Murray, Daniel D; Braun, Dominique; Kamel, Dena; Higgs, Elizabeth S; Hatlen, Timothy J; Kan, Virginia L; Sanchez, Adriana; Tierney, John; Denner, Eileen; Wentworth, Deborah; Babiker, Abdel G; Davey, Victoria J; Gelijns, Annetine C; Matthews, Gail V; Thompson, B Taylor; Lane, H Clifford; Neaton, James D; Lundgren, Jens D.
  • Mylonakis E; Division of Infectious Diseases, Rhode Island Hospital & The Miriam Hospital, Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: eleftherios_mylonakis@brown.edu.
  • Lutaakome J; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda.
  • Jain MK; U.T. Southwestern Medical Center and Parkland Health and Hospital Systems, Dallas, TX, USA.
  • Rogers AJ; Pulmonary, Allergy and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Moltó J; Lluita contra la Sida Foundation & Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III Health Institute, Madrid, Spain.
  • Benet S; Lluita contra la Sida Foundation & Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Mourad A; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.
  • Files DC; Division of Pulmonary, Critical Care, Allergy and Immunology, Department of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC.
  • Mugerwa H; Joint Clinical Research Centre, Lubowa and Gulu Regional Referral Hospital, Gulu, Uganda.
  • Kityo C; Joint Clinical Research Centre, Lubowa, Uganda.
  • Kiweewa F; Makerere University Lung Institute (MLI), Kampala, Uganda; Lira Regional Referral Hospital, Lira, Uganda.
  • Nalubega MG; Lira Regional Referral Hospital, Lira, Uganda.
  • Kitonsa J; Masaka Regional Referral Hospital, Masaka, Uganda.
  • Nabenkema E; St Francis Hospital, Nsambya, Uganda.
  • Murray DD; CHIP Center of Excellence for Health, Immunity, and Infections and Department of Infectious Diseases, Rigshospitalet; Copenhagen, Denmark.
  • Braun D; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich and Institute of Medical Virology, University of Zurich, Zurich Switzerland University Hospital Zurich, Zurich, Switzerland.
  • Kamel D; UT Southwestern Medical Center, Internal Medicine, Infectious Diseases, Dallas, TX, USA.
  • Higgs ES; National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
  • Hatlen TJ; Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Kan VL; Infectious Diseases Section, VA Medical Center, Washington, DC, USA.
  • Sanchez A; Washington DC VA Medical Center Washington, DC, USA.
  • Tierney J; Division of Clinical Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
  • Denner E; University of Minnesota, MN, USA.
  • Wentworth D; University of Minnesota, MN, USA.
  • Babiker AG; The Medical Research Council Clinical Trials Unit at UCL, University College London, London, UK.
  • Davey VJ; United States Department of Veterans Affairs; Washington, DC, USA.
  • Gelijns AC; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Matthews GV; The Kirby Institute, University of New South Wales, Sydney, Australia.
  • Thompson BT; Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital and Harvard Medical School; Boston, Massachusetts, USA.
  • Lane HC; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
  • Neaton JD; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
  • Lundgren JD; CHIP Center of Excellence for Health, Immunity, and Infections and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Med (N Y) ; 3(8): 531-537, 2022 08 12.
Article in English | MEDLINE | ID: covidwho-1983656
ABSTRACT
The protection provided by natural versus hybrid immunity from COVID-19 is unclear. We reflect on the challenges from trying to conduct a randomized post-SARS-CoV-2 infection vaccination trial study with rapidly evolving scientific data, vaccination guidelines, varying international policies, difficulties with vaccine availability, vaccine hesitancy, and a constantly evolving virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Med (N Y) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Med (N Y) Year: 2022 Document Type: Article