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THE BENEFICIAL EFFECT OF A MOUTHWASH CONTAINING A PHTHALOCYANINE DERIVATIVE IN PATIENTS HOSPITALIZED WITH COVID-19
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology ; 134(3):e224, 2022.
Article in English | ScienceDirect | ID: covidwho-1983768
ABSTRACT
Objectives To evaluate the clinical outcome, such as length of hospital stay (LOS), need for referral to the intensive care unit (ICU), and number of deaths of patients with COVID-19 with the use of a mouthwash containing a phthalocyanine derivative. Study Design A randomized triple-blind clinical trial in which a total of 41 hospitalized patients with COVID-19 were followed up. Patients were divided into 2 groups and both received a mouthwash containing active (AM) and nonactive (NAM) ingredients. They were instructed to use mouthwash and gargle for 1 minute 5 times a day and continue using the solution until discharge. Results The median LOS of the AM group was significantly shortened (4 days) compared with the NAM group (7 days;P = .0314). Additionally, gargling/rinsing with anionic phthalocyanine derivative was very helpful in reducing the severity of symptoms (no ICU care was needed) compared to not gargling/rinsing with APD (28.6% of patients in the NAM group needed ICU care, and 50% of this ICU subgroup died;P = .0207). Conclusions This study showed that the action of the mouthwash containing phthalocyanine derivatives had effects against SARS-CoV-2 and can reduce the symptoms of patients and reduce the length of hospital stay.

Full text: Available Collection: Databases of international organizations Database: ScienceDirect Type of study: Experimental Studies Language: English Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: ScienceDirect Type of study: Experimental Studies Language: English Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Year: 2022 Document Type: Article