Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs.
Tetrahedron Lett
; 104: 154012, 2022 Aug 17.
Article
in English
| MEDLINE | ID: covidwho-1984119
ABSTRACT
The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to spread around the world. GS-441524 is the parent nucleoside of remdesivir which is the first drug approved for the treatment of COVID-19, and demonstrates strong activity against SARS-Cov-2 in vitro and in vivo. Herein, we reported the synthesis of a series of deuterated GS-441524 analogs, which had deuterium atoms up to five at the ribose and the nucleobase moieties. Compared to GS-441524, all the deuterated compounds showed similar inhibitory activities against SARS-CoV-2 in vitro.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Tetrahedron Lett
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS