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Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients.
Alomar, Fadhel A; Alshakhs, Marai N; Abohelaika, Salah; Almarzouk, Hassan M; Almualim, Mohammed; Al-Ali, Amein K; Al-Muhanna, Fahad; Alomar, Mohammed F; Alhaddad, Mousa J; Almulaify, Mohammed S; Alessa, Faisal S; Alsalman, Ahmed S; Alaswad, Ahmed; Bidasee, Sean R; Alsaad, Hassan A; Alali, Rudaynah A; AlSheikh, Mona H; Akhtar, Mohammed S; Al Mohaini, Mohammed; Alsalman, Abdulkhaliq J; Alturaifi, Hussain; Bidasee, Keshore R.
  • Alomar FA; Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia. falomar@iau.edu.sa.
  • Alshakhs MN; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Abohelaika S; Clinical Pharmacology Department, Qatif Central Hospital, Ministry of Health, Qatif, Saudi Arabia.
  • Almarzouk HM; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Almualim M; Intenstive Care Unit, Qatif Central Hospital, Ministry of Health, Qatif, Saudi Arabia.
  • Al-Ali AK; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Al-Muhanna F; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Alomar MF; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Alhaddad MJ; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Almulaify MS; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Alessa FS; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Alsalman AS; Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
  • Alaswad A; Clinical Pharmacology Department, Qatif Central Hospital, Ministry of Health, Qatif, Saudi Arabia.
  • Bidasee SR; Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Alsaad HA; Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.
  • Alali RA; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • AlSheikh MH; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Akhtar MS; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Al Mohaini M; Basic Sciences Department, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Al Ahsa, 31982, Saudi Arabia.
  • Alsalman AJ; Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia.
  • Alturaifi H; King Fahad Hospital Hofuf, Alahsa, Saudi Arabia.
  • Bidasee KR; Departments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA. kbidasee@unmc.edu.
Sci Rep ; 12(1): 9510, 2022 06 09.
Article in English | MEDLINE | ID: covidwho-1984409
ABSTRACT
Biomarkers to identify ICU COVID-19 patients at high risk for mortality are urgently needed for therapeutic care and management. Here we found plasma levels of the glycolysis byproduct methylglyoxal (MG) were 4.4-fold higher in ICU patients upon admission that later died (n = 33), and 1.7-fold higher in ICU patients that survived (n = 32),compared to uninfected controls (n = 30). The increased MG in patients that died correlated inversely with the levels of the MG-degrading enzyme glyoxalase-1 (r2 = - 0.50), and its co-factor glutathione (r2 = - 0.63), and positively with monocytes (r2 = 0.29). The inflammation markers, SSAO (r2 = 0.52), TNF-α (r2 = 0.41), IL-1ß (r2 = 0.25), CRP (r2 = 0.26) also correlated positively with MG. Logistic regression analysis provides evidence of a significant relationship between the elevated MG upon admission into ICU and death (P < 0.0001), with 42% of the death variability explained. From these data we conclude that elevated plasma MG on admission is a novel independent biomarker that predicts mortality in ICU COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Intensive Care Units Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-12751-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Intensive Care Units Type of study: Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-12751-y