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Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation.
Alteri, Claudia; Scutari, Rossana; Costabile, Valentino; Colagrossi, Luna; Yu La Rosa, Katia; Agolini, Emanuele; Lanari, Valentina; Chiurchiù, Sara; Romani, Lorenza; Markowich, Anna Hermine; Bernaschi, Paola; Russo, Cristina; Novelli, Antonio; Bernardi, Stefania; Campana, Andrea; Villani, Alberto; Perno, Carlo Federico.
  • Alteri C; Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Scutari R; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
  • Costabile V; Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Colagrossi L; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
  • Yu La Rosa K; Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Agolini E; Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Lanari V; Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Chiurchiù S; Multimodal Research Area, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Romani L; Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Markowich AH; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Bernaschi P; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Russo C; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Novelli A; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Bernardi S; Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Campana A; Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Villani A; Microbiology and Diagnostics of Immunology Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
  • Perno CF; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.
Sci Rep ; 12(1): 10194, 2022 06 17.
Article in English | MEDLINE | ID: covidwho-1984424
ABSTRACT
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections' frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Child / Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-14426-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Child / Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-14426-0