Herpesvirus and neurological manifestations in patients with severe coronavirus disease.
Virol J
; 19(1): 101, 2022 06 08.
Article
in English
| MEDLINE | ID: covidwho-1986835
ABSTRACT
BACKGROUND:
Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.METHODS:
We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.RESULTS:
Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).CONCLUSIONS:
The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Herpesvirus 6, Human
/
Herpesvirus 7, Human
/
Herpesviridae Infections
/
COVID-19
/
Herpesviridae
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Virol J
Journal subject:
Virology
Year:
2022
Document Type:
Article
Affiliation country:
S12985-022-01828-9
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