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Herpesvirus and neurological manifestations in patients with severe coronavirus disease.
Carneiro, Vanessa Cristine de Souza; Alves-Leon, Soniza Vieira; Sarmento, Dmitry José de Santana; Coelho, Wagner Luis da Costa Nunes Pimentel; Moreira, Otacilio da Cruz; Salvio, Andreza Lemos; Ramos, Carlos Henrique Ferreira; Ramos Filho, Carlos Henrique Ferreira; Marques, Carla Augusta Barreto; da Costa Gonçalves, João Paulo; Leon, Luciane Almeida Amado; de Paula, Vanessa Salete.
  • Carneiro VCS; Laboratory of Molecular Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
  • Alves-Leon SV; Laboratory of Technological Development in Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
  • Sarmento DJS; Department of Neurology/Reference and Research Center for Multiple Sclerosisand Other Central Nervous System Idiopathic Demyelinating Inflammatory Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Coelho WLDCNP; Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil.
  • Moreira ODC; Department of Oral Diagnosis, School of Dentistry, State University of Paraíba, Araruna, PB, Brazil.
  • Salvio AL; Laboratory of Technological Development in Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
  • Ramos CHF; Laboratory of Molecular Virology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
  • Ramos Filho CHF; Real Time PCR Platform RPT09A, Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
  • Marques CAB; Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil.
  • da Costa Gonçalves JP; Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil.
  • Leon LAA; Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil.
  • de Paula VS; Laboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIO, Rio de Janeiro, Brazil.
Virol J ; 19(1): 101, 2022 06 08.
Article in English | MEDLINE | ID: covidwho-1986835
ABSTRACT

BACKGROUND:

Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.

METHODS:

We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.

RESULTS:

Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).

CONCLUSIONS:

The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 6, Human / Herpesvirus 7, Human / Herpesviridae Infections / COVID-19 / Herpesviridae Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Virol J Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: S12985-022-01828-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 6, Human / Herpesvirus 7, Human / Herpesviridae Infections / COVID-19 / Herpesviridae Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Virol J Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: S12985-022-01828-9