Your browser doesn't support javascript.
Tranexamic Acid and Plasminogen/Plasmin Glaring Paradox in COVID-19.
Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Al-Harcan, Nasser A Hadi; Alexiou, Athanasios; Batiha, Gaber El-Saber.
  • Al-Kuraishy HM; Department of clinical pharmacology and medicine, college of medicine, ALmustansiriyia University, Baghdad, Iraq.
  • Al-Gareeb AI; Department of clinical pharmacology and medicine, college of medicine, ALmustansiriyia University, Baghdad, Iraq.
  • Al-Harcan NAH; Department of clinical pharmacology and medicine, College of Medicine, Al-Rasheed University College, Bagdad, Iraq.
  • Alexiou A; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, Australia.
  • Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt.
Endocr Metab Immune Disord Drug Targets ; 2022 Aug 01.
Article in English | MEDLINE | ID: covidwho-2238464
ABSTRACT
Coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory distress syndrome, coronavirus type 2 (SARS-CoV-2), leading to acute tissue injury and an overstated immune response. In COVID-19, there are noteworthy changes in the fibrinolytic system with the development of coagulopathy. Therefore, modulation of the fibrinolytic system may affect the course of COVID-19. Tranexamic acid (TXA) is an anti-fibrinolytic drug that reduces the conversion of plasminogen to plasmin, which is necessary for SARS-CoV-2 infectivity. In addition, TXA has anti-inflammatory, anti-platelet, and anti-thrombotic effects, which may attenuate the COVID-19 severity. Thus, in this narrative review, we try to find the beneficial and harmful effects of TXA in COVID-19.
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2022 Document Type: Article Affiliation country: 1871530322666220801102402

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2022 Document Type: Article Affiliation country: 1871530322666220801102402