Phytochemical Contents, Biological Activities and Therapeutic Applications of Hedera Helix (Ivy Leaf) Extracts: A Review
Natural Products Journal
; 12(4):22-32, 2022.
Article
in English
| EMBASE | ID: covidwho-1987310
ABSTRACT
Background:
Herbs have long been used as natural therapeutics, and recent controlled clinical studies have confirmed some of the presumed benefits. Hedera helix(ivy leaves) is a valuable common form related to the family Araliaceae. Many herbal preparations include extracts from their leaves as the principle active ingredient.Objective:
The objective of this article is to summarize the pharmacological activities and phyto-chemical screening of H. helix.Methods:
To prepare this article, the data was collected from different sources, including books, th-esis, research and etc.Results:
The all-published studies depend on isolation, identification, and characterization of different active constituents of H. helix leaves, followed by the determination of biological activities in vivo and in vivo. Chemical screening has shown that H. helix leaves are a rich source of phytochem-icals demonstrating therapeutic activities, such as sterols, tannins, terpenoids, glycosides, phenols, emetine alkaloids, flavonoids, saponins, volatile and fixed oils, vitamins, carbohydrates, reducing sugars, and minerals. Further, studies of disease models and clinical trials have demonstrated an-ti-inflammatory, analgesic, cough suppressant, expectorant, anticancer, antimicrobial, anticoagu-lant, and smooth muscle relaxant activities.Conclusion:
This review summarizes the bioactive constituents of H. helix leaves and their under-lying pharmacological mechanisms, clinical efficacies, and safety profiles. We also suggest potential therapeutic uses for COVID-19.
animal experiment; animal model; biological activity; coronavirus disease 2019; drug activity; drug efficacy; drug mechanism; drug safety; drug therapy; human; in vivo study; ivy; LD50; malignant neoplasm; nonhuman; plant leaf; review; analgesic agent; antiinfective agent; antitussive agent; carbohydrate; emetine; expectorant agent; flavonoid; glycoside; hedelix; mineral; phenol derivative; phytochemical; saponin; spasmolytic agent; sterol; tannin derivative; terpenoid; vitamin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Natural Products Journal
Year:
2022
Document Type:
Article
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