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Phytochemical Contents, Biological Activities and Therapeutic Applications of Hedera Helix (Ivy Leaf) Extracts: A Review
Natural Products Journal ; 12(4):22-32, 2022.
Article in English | EMBASE | ID: covidwho-1987310
ABSTRACT

Background:

Herbs have long been used as natural therapeutics, and recent controlled clinical studies have confirmed some of the presumed benefits. Hedera helix(ivy leaves) is a valuable common form related to the family Araliaceae. Many herbal preparations include extracts from their leaves as the principle active ingredient.

Objective:

The objective of this article is to summarize the pharmacological activities and phyto-chemical screening of H. helix.

Methods:

To prepare this article, the data was collected from different sources, including books, th-esis, research and etc.

Results:

The all-published studies depend on isolation, identification, and characterization of different active constituents of H. helix leaves, followed by the determination of biological activities in vivo and in vivo. Chemical screening has shown that H. helix leaves are a rich source of phytochem-icals demonstrating therapeutic activities, such as sterols, tannins, terpenoids, glycosides, phenols, emetine alkaloids, flavonoids, saponins, volatile and fixed oils, vitamins, carbohydrates, reducing sugars, and minerals. Further, studies of disease models and clinical trials have demonstrated an-ti-inflammatory, analgesic, cough suppressant, expectorant, anticancer, antimicrobial, anticoagu-lant, and smooth muscle relaxant activities.

Conclusion:

This review summarizes the bioactive constituents of H. helix leaves and their under-lying pharmacological mechanisms, clinical efficacies, and safety profiles. We also suggest potential therapeutic uses for COVID-19.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Natural Products Journal Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Natural Products Journal Year: 2022 Document Type: Article