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Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022.
Amati, Rebecca; Frei, Anja; Kaufmann, Marco; Sabatini, Serena; Pellaton, Céline; Fehr, Jan; Albanese, Emiliano; Puhan, Milo A.
  • Amati R; Università della Svizzera Italiana, Facoltà di scienze biomediche, Lugano, Ticino, Switzerland.
  • Frei A; Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Kaufmann M; Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Sabatini S; Università della Svizzera Italiana, Facoltà di scienze biomediche, Lugano, Ticino, Switzerland.
  • Pellaton C; Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, and University of Lausanne, Lausanne, Switzerland.
  • Fehr J; Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Albanese E; Università della Svizzera Italiana, Facoltà di scienze biomediche, Lugano, Ticino, Switzerland.
  • Puhan MA; Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland.
Euro Surveill ; 27(31)2022 08.
Article in English | MEDLINE | ID: covidwho-1987417
ABSTRACT
Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI 96.8-98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.ES.2022.27.31.2200561

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Humans / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: 1560-7917.ES.2022.27.31.2200561