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Long-Term Health Symptoms and Sequelae Following SARS-CoV-2 Infection: An Evidence Map.
Franco, Juan Victor Ariel; Garegnani, Luis Ignacio; Oltra, Gisela Viviana; Metzendorf, Maria-Inti; Trivisonno, Leonel Fabrizio; Sgarbossa, Nadia; Ducks, Denise; Heldt, Katharina; Mumm, Rebekka; Barnes, Benjamin; Scheidt-Nave, Christa.
  • Franco JVA; Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
  • Garegnani LI; Research Department, Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires C1199, Argentina.
  • Oltra GV; Research Department, Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires C1199, Argentina.
  • Metzendorf MI; Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
  • Trivisonno LF; Department of Health Science, Universidad Nacional de La Matanza, Buenos Aires B1754JEC, Argentina.
  • Sgarbossa N; Department of Health Science, Universidad Nacional de La Matanza, Buenos Aires B1754JEC, Argentina.
  • Ducks D; Department of Epidemiology and Health Monitoring, Robert Koch-Institute, 13353 Berlin, Germany.
  • Heldt K; Department of Epidemiology and Health Monitoring, Robert Koch-Institute, 13353 Berlin, Germany.
  • Mumm R; Department of Epidemiology and Health Monitoring, Robert Koch-Institute, 13353 Berlin, Germany.
  • Barnes B; Department of Epidemiology and Health Monitoring, Robert Koch-Institute, 13353 Berlin, Germany.
  • Scheidt-Nave C; Department of Epidemiology and Health Monitoring, Robert Koch-Institute, 13353 Berlin, Germany.
Int J Environ Res Public Health ; 19(16)2022 08 11.
Article in English | MEDLINE | ID: covidwho-1987750
ABSTRACT
Post-COVID-19 conditions, also known as 'Long-COVID-19', describe a longer and more complex course of illness than acute COVID-19 with no widely accepted uniform case definition. We aimed to map the available evidence on persistent symptoms and sequelae following SARS-CoV-2 in children and adults. We searched the Cochrane COVID-19 Study Register and the WHO COVID-19 Global literature on coronavirus disease database on 5 November 2021. We included longitudinal and cross-sectional studies and we extracted their characteristics, including the type of core outcomes for post-COVID-19 conditions. We included 565 studies (657 records). Most studies were uncontrolled cohort studies. The median follow-up time was 13 weeks (IQR 9 to 24). Only 72% of studies were conducted in high-income countries, 93% included unvaccinated adults with mild-to-critical disease, only 10% included children and adolescents, and less than 5% included children under the age of five. While most studies focused on health symptoms, including respiratory symptoms (71%), neurological symptoms (57%), fatigue (54%), pain (50%), mental functioning (43%), cardiovascular functioning (40%), and post-exertion symptoms (28%), cognitive function (26%), fewer studies assessed other symptoms such as overall recovery (24%), the need for rehabilitation (18%), health-related quality of life (16%), changes in work/occupation and study (10%), or survival related to long-COVID-19 (4%). There is a need for controlled cohort studies with long-term follow-up and a focus on overall recovery, health-related quality of life, and the ability to perform daily tasks. Studies need to be extended to later phases of the pandemic and countries with low resources.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Long Covid Limits: Adolescent / Adult / Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19169915

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Long Covid Limits: Adolescent / Adult / Child / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19169915