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An Experimental Model of Neuro-Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells.
Frutos-Rincón, Laura; Gómez-Sánchez, José Antonio; Íñigo-Portugués, Almudena; Acosta, M Carmen; Gallar, Juana.
  • Frutos-Rincón L; Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain.
  • Gómez-Sánchez JA; The European University of Brain and Technology-NeurotechEU, 03550 San Juan de Alicante, Spain.
  • Íñigo-Portugués A; Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain.
  • Acosta MC; Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain.
  • Gallar J; Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain.
Int J Mol Sci ; 23(6)2022 Mar 10.
Article in English | MEDLINE | ID: covidwho-1987822
ABSTRACT
The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the lack of myelinated nerves (although it is extremely innervated), the tightly controlled hydration state, and the absence of blood and lymphatic vessels in healthy conditions, among others. The avascular, immune-privileged tissue of the cornea is an ideal model to study the interactions between its well-characterized and dense sensory nerves (easily accessible for both focal electrophysiological recording and morphological studies) and the low number of resident immune cell types, distinguished from those cells migrating from blood vessels. This paper presents an overview of the corneal structure and innervation, the resident dendritic cell (DC) subpopulations present in the cornea, their distribution in relation to corneal nerves, and their role in ocular inflammatory diseases. A mouse model in which sensory axons are constitutively labeled with tdTomato and DCs with green fluorescent protein (GFP) allows further analysis of the neuro-immune crosstalk under inflammatory and steady-state conditions of the eye.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimmunomodulation / Cornea Type of study: Experimental Studies Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23062997

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimmunomodulation / Cornea Type of study: Experimental Studies Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23062997