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Serological Response and Relationship with Gender-Sensitive Variables among Healthcare Workers after SARS-CoV-2 Vaccination.
Cangemi, Roberto; Di Franco, Manuela; Angeloni, Antonio; Zicari, Alessandra; Cardinale, Vincenzo; Visentini, Marcella; Antonelli, Guido; Napoli, Anna; Anastasi, Emanuela; Romiti, Giulio Francesco; d'Alba, Fabrizio; Alvaro, Domenico; Polimeni, Antonella; Basili, Stefania.
  • Cangemi R; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Di Franco M; Department of Internal Clinical, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00185 Roma, Italy.
  • Angeloni A; Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Zicari A; Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Cardinale V; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Roma, Italy.
  • Visentini M; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Antonelli G; Department of Molecular Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Napoli A; Department of Molecular Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Anastasi E; Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Romiti GF; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • d'Alba F; General Direction, Umberto I Hospital, 00161 Roma, Italy.
  • Alvaro D; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
  • Polimeni A; Department of Oral and Maxillofacial Science, Sapienza University of Rome, 00185 Roma, Italy.
  • Basili S; Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Roma, Italy.
J Pers Med ; 12(6)2022 Jun 18.
Article in English | MEDLINE | ID: covidwho-1987865
ABSTRACT
Vaccine-induced immunity is a key strategy in the long-term control of the COVID-19 pandemic. The aim of our study was to explore the relationship between mRNA vaccine-induced antibodies and gender-sensitive variables among healthcare workers. Two thousand-sixty-five volunteers who received the BNT162b2 vaccine were enrolled in the study and followed up. Demographic, clinical, and social variables (educational level, marital status, occupation, childcare) were evaluated through a self-administered questionnaire. Anti-Spike (S) IgG were measured at 1 month (T1) and at 5 months (T2) after the second vaccine dose. At T1, median anti-S IgG values were 693 [394->800] AU/mL (1 AU = 2.6 BAU). Values > 800 AU/mL (2080 BAU/mL) were directly associated with a previous COVID-19 (p < 0.001) infection and inversely with age (p < 0.001), smoking habit (p < 0.001), and autoimmune diseases (p < 0.001). At T2, a significant decreasing in anti-S IgG values was observed (187 [81-262] AU/mL), with a median decrease of 72 [60-82]%. On multivariate data analysis, a reduction of more than 82% was directly associated with male sex (p < 0.021), age (p < 0.001), smoking (p = 0.038), hypertension (p = 0.042), and, inversely, with previous COVID-19 infection (p < 0.001) and being "cohabiting" (p = 0.005). Our findings suggest that demographic, clinical, and social variables play a role in anti-S IgG values decreasing in long-term follow up and should be considered to find personalized vaccine schedules.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12060994

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12060994