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High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021.
Iwamoto, Chelsea; Lesteberg, Kelsey E; Lamb, Molly M; Calvimontes, Diva M; Guo, Kejun; Barrett, Bradley S; Mickens, Kaylee L; Duca, Lindsey M; Monzon, Jose; Chard, Anna N; Guzman, Gerber; Barrios, Edgar; Rojop, Neudy; Arias, Kareen; Gomez, Melissa; Paiz, Claudia; Bolanos, Guillermo Antonio; Edwards, Kathryn M; Zielinski Gutierrez, Emily; Azziz-Baumgartner, Eduardo; Asturias, Edwin J; Santiago, Mario L; Beckham, J David; Olson, Daniel.
  • Iwamoto C; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
  • Lesteberg KE; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.
  • Lamb MM; Department of Epidemiology and Center for Global Health, Colorado School of Public Health, 13199 E. Montview Blvd, Aurora, CO 80045, USA.
  • Calvimontes DM; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Guo K; La Comisión Presidencial de Atención a la Emergencia COVID-19 (Coprecovid), Guatemala City 01010, Guatemala.
  • Barrett BS; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.
  • Mickens KL; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.
  • Duca LM; Division of Infectious Diseases, Department of Medicine, University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.
  • Monzon J; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
  • Chard AN; Centers for Disease Control and Prevention, Division of Global Health Protection (CDC-DGHP), 1600 Clifton Rd., Atlanta, GA 30329, USA.
  • Guzman G; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
  • Barrios E; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Rojop N; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Arias K; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Gomez M; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Paiz C; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Bolanos GA; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Edwards KM; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Zielinski Gutierrez E; Division of Infectious Disease, Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children's Way, 6th Floor, Nashville, TN 37232, USA.
  • Azziz-Baumgartner E; Centers for Disease Control and Prevention, Division of Global Health Protection (CDC-DGHP), 1600 Clifton Rd., Atlanta, GA 30329, USA.
  • Asturias EJ; Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
  • Santiago ML; Department of Epidemiology and Center for Global Health, Colorado School of Public Health, 13199 E. Montview Blvd, Aurora, CO 80045, USA.
  • Beckham JD; Center for Human Development, Fundación para la Salud Integral de los Guatemaltecos, FSIG, Km 30 carretera de Coatepeque a Chiquirines Caballo Blanco, Retalhuleu 11010, Guatemala.
  • Olson D; La Comisión Presidencial de Atención a la Emergencia COVID-19 (Coprecovid), Guatemala City 01010, Guatemala.
Vaccines (Basel) ; 10(7)2022 Jul 21.
Article in English | MEDLINE | ID: covidwho-1988047
ABSTRACT
Essential agricultural workers work under occupational conditions that may increase the risk of SARS-CoV-2 exposure and transmission. Data from an agricultural worker cohort in Guatemala, and anti-SARS-CoV-2 nucleocapsid IgG (anti-N IgG) testing were used to estimate past infections and analyze risk factors associated with seropositivity at enrollment and association with SARS-CoV-2 infection. The stability of neutralizing antibody (NAb) responses were assessed in a subset of participants. The adjusted relative risk (aRR) for seroprevalence at enrollment was estimated accounting for correlations within worksites. At enrollment, 616 (46.2%) of 1334 (93.2%) participants had anti-N IgG results indicating prior SARS-CoV-2 infection. A cough ≤ 10 days prior to enrollment (aRR = 1.28, 95% CI 1.13-1.46) and working as a packer (aRR = 2.00, 95% CI 1.67-2.38) or packing manager within the plants (aRR = 1.82, 95% CI 1.36-2.43) were associated with increased risk of seropositivity. COVID-19 incidence density among seronegative workers was 2.3/100 Person-Years (P-Y), higher than seropositive workers (0.4/100 P-Y). Most workers with follow-up NAb testing (65/77, 84%) exhibited a 95% average decrease in NAb titers in <6 months. While participants seropositive at baseline were less likely to experience a symptomatic SARS-CoV-2 infection during follow-up, NAb titers rapidly waned, underscoring the need for multipronged COVID-19 prevention strategies in the workplace, including vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Central America / Guatemala Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10071160

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Central America / Guatemala Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10071160