MONITORING OF COVID-19 VACCINATION IN PREGNANT WOMEN OF SIBERIA AND THE RUSSIAN FAR EAST

ABSTRACT

Objective: To evaluate the dynamics of vaccination against the new coronavirus infection COVID-19 in pregnant women in the Far Eastern and Siberian Federal Districts from October 29, 2021 to December 24, 2021. Materials and methods: A total of 127787 pregnant women were monitored for vaccination from October 29, 2021 to December 24, 2021 in 11 regions of the Far Eastern Federal District and 10 regions of the Siberian Federal District. The findings were presented by the chief obstetricians-gynecologists of the regions. Statistical processing of the obtained data was carried out using the software package Microsoft Excel 2007. The level of null hypothesis testing was considered to be statistically significant at p<0.05. Results: According to the presented data, 126897 pregnant women were registered in the regions of the Far East and Siberia as of October 29, 2021, and 127787 women as of December 24, 2021. The results of the study showed an extremely low percentage of preconception specific prevention in pregnant women in the Far East and Siberia as of October 29, 2021. This indicator increased within two months by more than 2.26 times, namely from 4.2% to 9.5%. During monitoring, the proportion of vaccinated women before 22 weeks gestation increased by 2.1 times, from 0.7 to 1.5%;after 22 weeks gestation, it increased by 3.7 times, from 1.5 to 5.5%. The proportion of pregnant women who were ill with COVID-19 or vaccinated in the regions of the Far Eastern and Siberian Federal Districts increased from 13.0% to 26.3% during the monitoring period (p<0.001). There were no serious adverse events during COVID-19 vaccination with the Gam-COVID-Vac vaccine (Sputnik V) in 9667 pregnant women. Conclusion: Despite the absence of serious adverse events during COVID-19 vaccination with the Gam-COVID-Vac (Sputnik V) vaccine in pregnant women, it is necessary to conduct further detailed studies of the safety of vaccination during pregnancy, and also to develop a set of organizational measures aimed at increasing compliance with vaccination against COVID-19 at the period of pregnancy planning.