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Nirmatrelvir-remdesivir association for non-hospitalized adults with COVID-19, point of view.
Ferrara, Francesco; Zovi, Andrea; Trama, Ugo; Vitiello, Antonio.
  • Ferrara F; Pharmaceutical Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, Nola, 80035, Naples, Italy. ferrarafr@libero.it.
  • Zovi A; Department of Pharmaceutical Sciences, University of Milan, Via G. Colombo, 71-20133, Milan, Italy.
  • Trama U; Campania Regional Health System, Naples, Italy.
  • Vitiello A; Pharmaceutical Department, Usl Umbria 1, Via XIV Settembre-75, Perugia, Italy.
Inflammopharmacology ; 30(5): 1927-1931, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1990702
ABSTRACT
The efforts of the scientific world directed to identifying new antiviral drugs and therapies effective against SARS-CoV-2 continue. New oral antivirals against SARS-CoV-2 such as paxlovid have recently authorized. Evidence shows that these antivirals have good efficacy in reducing the risk of hospitalization in COVID-19 positive patients. Remdesivir is an authorized antiviral for the treatment of SARS-CoV-2 infection. To date, there are still few data in the literature on the safety profile and the risk of generating antiviral-resistant SARS-CoV-2 drug variants. In this manuscript we describe the evidence in the literature on the monotherapy use of paxlovid and monotherapy use of remdesivir, and the scientific hypothesis of using nirmatrelvir and remdesivir in association with the aim of increasing treatment efficacy, reducing the risk of adverse reactions and generating antiviral drug-resistant variants.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Variants Limits: Adult / Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: S10787-022-01055-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / COVID-19 Drug Treatment Type of study: Prognostic study Topics: Variants Limits: Adult / Humans Language: English Journal: Inflammopharmacology Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: S10787-022-01055-2