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Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
Parker, Edyth; Anderson, Catelyn; Zeller, Mark; Tibi, Ahmad; Havens, Jennifer L; Laroche, Geneviève; Benlarbi, Mehdi; Ariana, Ardeshir; Robles-Sikisaka, Refugio; Latif, Alaa Abdel; Watts, Alexander; Awidi, Abdalla; Jaradat, Saied A; Gangavarapu, Karthik; Ramesh, Karthik; Kurzban, Ezra; Matteson, Nathaniel L; Han, Alvin X; Hughes, Laura D; McGraw, Michelle; Spencer, Emily; Nicholson, Laura; Khan, Kamran; Suchard, Marc A; Wertheim, Joel O; Wohl, Shirlee; Côté, Marceline; Abdelnour, Amid; Andersen, Kristian G; Abu-Dayyeh, Issa.
  • Parker E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. eparker@scripps.edu.
  • Anderson C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Zeller M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Tibi A; Biolab Diagnostic Laboratories, Amman, Jordan.
  • Havens JL; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA, USA.
  • Laroche G; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada.
  • Benlarbi M; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada.
  • Ariana A; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada.
  • Robles-Sikisaka R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Latif AA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Watts A; Bluedot, Toronto, ON, Canada.
  • Awidi A; Cell Therapy Center, The University of Jordan, Amman, Jordan.
  • Jaradat SA; Thrombosis, haemostasis laboratory, School of Medicine, The University of Jordan, Amman, Jordan.
  • Gangavarapu K; Princess Haya Biotechnology Center, Jordan University of Science and Technology, Irbid, Jordan.
  • Ramesh K; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Kurzban E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Matteson NL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Han AX; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Hughes LD; Department of Medical Microbiology & Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.
  • McGraw M; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Spencer E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Nicholson L; Scripps Research Translational Institute, La Jolla, CA, USA.
  • Khan K; Scripps Research Translational Institute, La Jolla, CA, USA.
  • Suchard MA; Bluedot, Toronto, ON, Canada.
  • Wertheim JO; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Wohl S; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Côté M; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Abdelnour A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Andersen KG; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada.
  • Abu-Dayyeh I; Biolab Diagnostic Laboratories, Amman, Jordan.
Nat Commun ; 13(1): 4784, 2022 08 15.
Article in English | MEDLINE | ID: covidwho-1991598
ABSTRACT
Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan's export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32536-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-32536-1