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Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2.
Takeda, Ryo; Sawa, Hirofumi; Sasaki, Michihito; Orba, Yasuko; Maishi, Nako; Tsumita, Takuya; Ushijima, Natsumi; Hida, Yasuhiro; Sano, Hidehiko; Kitagawa, Yoshimasa; Hida, Kyoko.
  • Takeda R; Vascular Biology and Molecular Pathology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
  • Sawa H; Oral Diagnosis and Medicine, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
  • Sasaki M; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Orba Y; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Maishi N; One Health Research Center, Hokkaido University, Sapporo, Japan.
  • Tsumita T; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Ushijima N; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Hida Y; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Sano H; Vascular Biology and Molecular Pathology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
  • Kitagawa Y; Vascular Biology and Molecular Pathology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
  • Hida K; Support Section for Education and Research, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
Sci Rep ; 12(1): 14050, 2022 08 18.
Article in English | MEDLINE | ID: covidwho-1991675
ABSTRACT
Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 µg/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cetylpyridinium / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-18367-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cetylpyridinium / COVID-19 Drug Treatment Type of study: Experimental Studies Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-18367-6