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Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19.
Regino-Zamarripa, Nora E; Ramírez-Martínez, Gustavo; Jiménez-Álvarez, Luis Armando; Cruz-Lagunas, Alfredo; Gómez-García, Itzel Alejandra; Ignacio-Cortés, Sergio; Márquez-García, José Eduardo; Pacheco-Hernández, Lynette Miroslava; Ramírez-Noyola, Jazmín Ariadna; Barquera, Rodrigo; Mendoza-Milla, Criselda; Luna-Rivero, Cesar; Domínguez-Cherit, José Guillermo; Ramírez-Rangel, Remedios; Rodríguez-Reyna, Tatiana Sofía; Hernández-Cárdenas, Carmen M; Choreño-Parra, José Alberto; León-Ávila, Gloria; Zúñiga, Joaquín.
  • Regino-Zamarripa NE; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Ramírez-Martínez G; Programa de Doctorado en Ciencias Quimicobiológicas, Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio and Plan de Ayala s/n, Mexico City, Mexico.
  • Jiménez-Álvarez LA; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
  • Cruz-Lagunas A; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Gómez-García IA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Ignacio-Cortés S; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Márquez-García JE; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Pacheco-Hernández LM; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
  • Ramírez-Noyola JA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Barquera R; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
  • Mendoza-Milla C; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Luna-Rivero C; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Domínguez-Cherit JG; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
  • Ramírez-Rangel R; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • Rodríguez-Reyna TS; Programa de Maestría en Ciencias de la Salud, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón and Plan de San Luis, Mexico City, Mexico.
  • Hernández-Cárdenas CM; Department of Archaeogenetics, Max Planck Institute for Science of Human History, Jena, Germany.
  • Choreño-Parra JA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
  • León-Ávila G; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
  • Zúñiga J; Deparment of Pathology, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City, Mexico.
J Interferon Cytokine Res ; 42(8): 430-443, 2022 08.
Article in English | MEDLINE | ID: covidwho-2278024
ABSTRACT
Interferon-induced transmembrane (IFITM) proteins mediate protection against enveloped viruses by blocking membrane fusion at endosomes. IFITM1 and IFITM3 are crucial for protection against influenza, and various single nucleotide polymorphisms altering their function have been linked to disease susceptibility. However, bulk IFITM1 and IFITM3 mRNA expression dynamics and their correlation with clinical outcomes have not been extensively addressed in patients with respiratory infections. In this study, we evaluated the expression of IFITM1 and IFITM3 in peripheral leukocytes from healthy controls and individuals with severe pandemic influenza A(H1N1) or coronavirus disease 2019 (COVID-19). Comparisons between participants grouped according to their clinical characteristics, underlying disease, and outcomes showed that the downregulation of IFITM1 was a distinctive characteristic of severe pandemic influenza A(H1N1) that correlated with outcomes, including mortality. Conversely, increased IFITM3 expression was a common feature of severe pandemic influenza A(H1N1) and COVID-19. Using a high-dose murine model of infection, we confirmed not only the downregulation of IFITM1 but also of IFITM3 in the lungs of mice with severe influenza, as opposed to humans. Analyses in the comparative cohort also indicate the possible participation of IFITM3 in COVID-19. Our results add to the evidence supporting a protective function of IFITM proteins against viral respiratory infections in humans.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antigens, Differentiation / RNA-Binding Proteins / Influenza, Human / COVID-19 / Membrane Proteins Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: J Interferon Cytokine Res Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: Jir.2022.0036

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antigens, Differentiation / RNA-Binding Proteins / Influenza, Human / COVID-19 / Membrane Proteins Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: J Interferon Cytokine Res Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: Jir.2022.0036