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B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity.
Oleinika, Kristine; Slisere, Baiba; Catalán, Diego; Rosser, Elizabeth C.
  • Oleinika K; Department of Internal Diseases, Riga Stradins University, Riga, Latvia.
  • Slisere B; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Catalán D; Department of Doctoral Studies, Riga Stradins University, Riga, Latvia.
  • Rosser EC; Joint Laboratory, Pauls Stradins Clinical University Hospital, Riga, Latvia.
Clin Exp Immunol ; 2022 Aug 12.
Article in English | MEDLINE | ID: covidwho-1992119
ABSTRACT
Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cei

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Cei