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Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients.
Karaba, Andrew H; Zhou, Weiqiang; Li, Shuai; Aytenfisu, Tihitina Y; Johnston, Trevor S; Akinde, Olivia; Eby, Yolanda; Abedon, Aura T; Alejo, Jennifer L; Qin, Caroline X; Thompson, Elizabeth A; Garonzik-Wang, Jacqueline M; Blankson, Joel N; Cox, Andrea L; Bailey, Justin R; Klein, Sabra L; Pekosz, Andrew; Segev, Dorry L; Tobian, Aaron A R; Werbel, William A.
  • Karaba AH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Zhou W; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Li S; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Aytenfisu TY; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Johnston TS; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Akinde O; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Eby Y; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Abedon AT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Alejo JL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Qin CX; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Thompson EA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Garonzik-Wang JM; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Blankson JN; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bailey JR; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Klein SL; Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Pekosz A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Segev DL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Tobian AAR; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Werbel WA; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clin Infect Dis ; 2022 Aug 12.
Article in English | MEDLINE | ID: covidwho-1992159
ABSTRACT
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid