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Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019: A Prospective Cohort Study of 46 000 Healthcare Workers.
Kristensen, Jonas Henrik; Bo Hasselbalch, Rasmus; Pries-Heje, Mia; Nielsen, Pernille Brok; Dehlbæk Knudsen, Andreas; Fogh, Kamille; Boesgaard Norsk, Jakob; Eiken, Aleksander; Andersen, Ove; Fischer, Thea Kølsen; Juul Jensen, Claus Antonio; Torp-Pedersen, Christian; Rungby, Jørgen; Ditlev, Sisse Bolm; Hageman, Ida; Møgelvang, Rasmus; Gybel-Brask, Mikkel; Dessau, Ram Benny; Sørensen, Erik; Harritshøj, Lene; Folke, Fredrik; Engel Møller, Maria Elizabeth; Benfield, Thomas; Ullum, Henrik; Sværke Jørgensen, Charlotte; Rye Ostrowski, Sisse; Dam Nielsen, Susanne; Bundgaard, Henning; Iversen, Kasper.
  • Kristensen JH; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Bo Hasselbalch R; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Pries-Heje M; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Nielsen PB; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Dehlbæk Knudsen A; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Fogh K; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Boesgaard Norsk J; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.
  • Eiken A; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Andersen O; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Fischer TK; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Juul Jensen CA; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Torp-Pedersen C; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.
  • Rungby J; Department of Infectious Disease, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.
  • Ditlev SB; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Hageman I; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Møgelvang R; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Gybel-Brask M; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Dessau RB; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Sørensen E; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls vej 1, Herlev, Denmark.
  • Harritshøj L; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Folke F; Department of Endocrinology and Copenhagen Center for Translational Research, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, Copenhagen, Denmark.
  • Engel Møller ME; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Benfield T; Department of Emergency and Department of Clinical Research, Copenhagen University Hospital, Amager og Hvidovre, Kettegård Alle 30, Hvidovre, Denmark.
  • Ullum H; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Sværke Jørgensen C; Department of Clinical Research, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.
  • Rye Ostrowski S; Department of Public Health, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Dam Nielsen S; Department of Clinical Biochemistry, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.
  • Bundgaard H; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.
  • Iversen K; Department of Clinical Research, Copenhagen University Hospital - Nordsjællands Hospital, Dyrehavevej 29, Hillerød, Denmark.
J Infect Dis ; 226(1): 6-10, 2022 08 12.
Article in English | MEDLINE | ID: covidwho-1992200
ABSTRACT

BACKGROUND:

The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19).

METHODS:

A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination.

RESULTS:

The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found.

CONCLUSIONS:

The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis