Decoding the Role of Temperature in RNA Virus Infections.
mBio
; 13(5): e0202122, 2022 10 26.
Article
in English
| MEDLINE | ID: covidwho-1992943
ABSTRACT
RNA viruses include respiratory viruses, such as coronaviruses and influenza viruses, as well as vector-borne viruses, like dengue and West Nile virus. RNA viruses like these encounter various environments when they copy themselves and spread from cell to cell or host to host. Ex vivo differences, such as geographical location and humidity, affect their stability and transmission, while in vivo differences, such as pH and host gene expression, impact viral receptor binding, viral replication, and the host immune response against the viral infection. A critical factor affecting RNA viruses both ex vivo and in vivo, and defining the outcome of viral infections and the direction of viral evolution, is temperature. In this minireview, we discuss the impact of temperature on viral replication, stability, transmission, and adaptation, as well as the host innate immune response. Improving our understanding of how RNA viruses function, survive, and spread at different temperatures will improve our models of viral replication and transmission risk analyses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA Virus Infections
/
RNA Viruses
/
West Nile virus
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
MBio
Year:
2022
Document Type:
Article
Affiliation country:
Mbio.02021-22
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