Medium-term impact of the SARS-CoV-2 mRNA vaccine against disease activity in patients with systemic lupus erythematosus.
Lupus Sci Med
; 9(1)2022 08.
Article
in English
| MEDLINE | ID: covidwho-1993063
ABSTRACT
OBJECTIVES:
Numerous case reports have referred to new onset or flare of SLE after SARS-CoV-2 messenger RNA (mRNA) vaccines. Several observational studies showed that the short-term flare rate of SLE after SARS-CoV-2 vaccination is low. However, well-controlled clinical surveys are unavailable and the medium-term impact of the SARS-CoV-2 mRNA vaccines against the flare of SLE is uncertain. Therefore, we aimed to analyse the association between vaccination and medium-term subjective and objective disease activities of SLE and flares using matched pair methods.METHODS:
Altogether, 150 patients with SLE from the Kyoto Lupus Cohort were included. Patients who received two doses of the SARS-CoV-2 mRNA vaccines were 11 matched with unvaccinated patients based on the first vaccination date. The outcome measures were the SLE Disease Activity Index-2000 (SLEDAI-2K), the Japanese version of the SLE Symptom Checklist Questionnaire (SSC-J) and the Safety of Estrogens in Lupus Erythematosus National Assessment-SLEDAI flare index at 30, 60 and 90 days after vaccination.RESULTS:
SLEDAI-2K levels were not significantly different in vaccinated and unvaccinated patients with SLE at 30, 60 and 90 days after the second vaccination (adjusted estimate (95% CI) 30 days -0.46 (-1.48 to 0.56), p=0.39; 60 days 0.38 (-0.64 to 1.40), p=0.47; 90 days 0.40 (-0.54 to 1.34), p=0.41). Similar results were observed in the SSC-J score (adjusted estimate (95% CI), 30 days 0.05 (-1.46 to 1.56), p=0.95; 60 days -0.63 (-2.08 to 0.82), p=0.40; 90 days 0.27 (-1.04 to 1.58), p=0.69) and flare index (adjusted OR (95% CI), 30 days 0.81 (0.36 to 1.85), p=0.62; 60 days 1.13 (0.50 to 2.54), p=0.77; 90 days 0.85 (0.32 to 2.26), p=0.74).CONCLUSION:
SARS-CoV-2 vaccination did not significantly influence the medium-term subjective and objective disease activities or flares of SLE until 90 days after the second vaccination.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
/
Lupus Erythematosus, Systemic
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Lupus-2022-000727
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