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Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patients.
De Michele, Manuela; d'Amati, Giulia; Leopizzi, Martina; Iacobucci, Marta; Berto, Irene; Lorenzano, Svetlana; Mazzuti, Laura; Turriziani, Ombretta; Schiavo, Oscar G; Toni, Danilo.
  • De Michele M; Emergency Department, Stroke Unit, Sapienza University of Rome, Viale del Policlinico, 155, 00161, Rome, Italy. m.demichele@policlinicoumberto1.it.
  • d'Amati G; Department of Radiology, Oncology and Pathological Science, Sapienza University of Rome, Rome, Italy.
  • Leopizzi M; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latin, Italy.
  • Iacobucci M; Department of Human Neurosciences, Neuroradiology Unit, Sapienza University of Rome, Rome, Italy.
  • Berto I; Emergency Department, Stroke Unit, Sapienza University of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
  • Lorenzano S; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
  • Mazzuti L; Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Turriziani O; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Schiavo OG; Emergency Department, Stroke Unit, Sapienza University of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
  • Toni D; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
J Hematol Oncol ; 15(1): 108, 2022 08 16.
Article in English | MEDLINE | ID: covidwho-1993373
ABSTRACT
The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with acute ischemic stroke (by mechanical thrombectomy) and myocardial infarction. In this pilot study, we could detect SP, but not nucleocapsid protein, on platelets of COVID-19 patients' thrombi. In addition, in all three COVID-19 thrombi analyzed for molecular biology, no SARS-CoV-2 RNA could be detected by real-time polymerase chain reaction. These data could support the hypothesis that free SP, besides the whole virus, may be the trigger of platelet activation and clot formation in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Ischemic Stroke / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: J Hematol Oncol Journal subject: Hematology / Neoplasms Year: 2022 Document Type: Article Affiliation country: S13045-022-01329-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Ischemic Stroke / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: J Hematol Oncol Journal subject: Hematology / Neoplasms Year: 2022 Document Type: Article Affiliation country: S13045-022-01329-w