Human Milk Extracellular Vesicles: A Biological System with Clinical Implications.
Cells
; 11(15)2022 07 30.
Article
in English
| MEDLINE | ID: covidwho-1993937
ABSTRACT
The consumption of human milk by a breastfeeding infant is associated with positive health outcomes, including lower risk of diarrheal disease, respiratory disease, otitis media, and in later life, less risk of chronic disease. These benefits may be mediated by antibodies, glycoproteins, glycolipids, oligosaccharides, and leukocytes. More recently, human milk extracellular vesicles (hMEVs) have been identified. HMEVs contain functional cargos, i.e., miRNAs and proteins, that may transmit information from the mother to promote infant growth and development. Maternal health conditions can influence hMEV composition. This review summarizes hMEV biogenesis and functional contents, reviews the functional evidence of hMEVs in the maternal-infant health relationship, and discusses challenges and opportunities in hMEV research.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
MicroRNAs
/
Extracellular Vesicles
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Infant
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Cells11152345
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