Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.
Int J Mol Sci
; 23(15)2022 Jul 29.
Article
in English
| MEDLINE | ID: covidwho-1994079
ABSTRACT
We present a case report on an older woman with unspecific symptoms and predominant long-term gastrointestinal disturbances, acute overall health deterioration with loss of autonomy for daily activities, and cognitive impairment. Autopsy revealed the presence of alpha-synuclein deposits spread into intestinal mucosa lesions, enteric plexuses, pelvic and retroperitoneal nerves and ganglia, and other organs as well as Lewy pathology in the central nervous system (CNS). Moreover, we isolated norovirus from the patient, indicating active infection in the colon and detected colocalization of norovirus and alpha-synuclein in different regions of the patient's brain. In view of this, we report a concomitant norovirus infection with synthesis of alpha-synuclein in the gastrointestinal mucosa and Lewy pathology in the CNS, which might support Braak's hypothesis about the pathogenic mechanisms underlying synucleinopathies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Caliciviridae Infections
/
Lewy Body Disease
/
Norovirus
/
Cognitive Dysfunction
Type of study:
Case report
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms23158376
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