Antiviral effect and anti-COVID-19 potential of immunobiotics
Disease Surveillance
; 37(4):445-452, 2022.
Article
in Chinese
| CAB Abstracts | ID: covidwho-1994243
ABSTRACT
Immunobiotics, a group of probiotics, have the effect of anti-infection by regulating immune function, which can be added in in foods or used to make adjuvants or medicines (biologics). Immunobiotics can stimulate the mucosal immune system of the body, regulate innate and acquired immunity and exert non-specific anti-microbial (bacterial and viral) infection effects through oral, nasal mucosa, sublingual and other routes, but the immune regulation function of immunobiotics is species-specific. Oral administration of Lactobacillus plantarum GUANKE stimulated the increase and maintenance of SARS-CoV-2 neutralization antibodies in mice even 6 months after immunization. When L. plantarum GUANKE was given immediately after SARS-CoV-2 vaccination, the level of SARS-COV-2 specific neutralizing antibody in bronchoalveolar lavage increased by 8 times in mice, which improved the local and systematic cellular immune response to SARS-CoV-2 of mice. Clinical studies have found that immunobiotics have the auxiliary effect in the treatment of COVID-19 by mitigating the symptoms and increase the level of SARS-CoV-2 specific antibody of the patients. It is necessary to conduct research and evaluation for the appropriate guideline of immunobiotics use as erly as possible to provide a new option for the prevention and control of COVID-19.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Human Immunology and Allergology [VV055]; Animal Models of Human Diseases [VV400]; Animal and in vitro Models for Pharmaceuticals [VV450]; Host Resistance and Immunity [HH600]; Other Produce [QQ070]; Biological Control [HH100]; coronavirus disease 2019; viral diseases; pandemics; public health; antiviral properties; animal models; laboratory animals; disease models; bacterial diseases; adjuvants; probiotics; innate immune system; immunity; mucosa; immune system; mouth; nose; oral administration; biological control agents; biological control; neutralizing antibodies; immunization; vaccines; vaccination; health protection; disease prevention; medical treatment; symptoms; antibodies; early treatment; disease control; reviews; cell mediated immunity; natural enemies; immune sensitization; Severe acute respiratory syndrome coronavirus 2; mice; Lactobacillus plantarum; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Muridae; rodents; mammals; vertebrates; Chordata; animals; eukaryotes; Lactobacillus; Lactobacillaceae; Lactobacillales; Bacilli; Firmicutes; Bacteria; prokaryotes; immunobiotics; SARS-CoV-2; viral infections; anti-viral properties; bacterial infections; bacterioses; bacterium; mucous membrane; biological control organisms; biocontrol agents; biocontrol; cellular immunity
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Disease Surveillance
Year:
2022
Document Type:
Article
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