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An Assessment of a Rapid SARS-CoV-2 Antigen Test in Bangladesh.
Kawser, Zannat; Hossain, Mohabbat; Suliman, Sara; Lockman, Shahin; Gitaka, Jesse; Bandawe, Gama; Rahmat, Redwan; Hasan, Imrul; Siddik, Abu Bakar; Afrad, Mokibul Hassan; Rahman, Mohammed Ziaur; Miller, Glenn; Walt, David R; Ivers, Louise C; LaRocque, Regina C; Harris, Jason B; Qadri, Firdausi.
  • Kawser Z; Institute for Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh.
  • Hossain M; Institute for Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh.
  • Suliman S; Division of Experimental Medicine, Zuckerberg San Francisco General Hospital, San Francisco, California.
  • Lockman S; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts.
  • Gitaka J; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Bandawe G; Directorate of Research and Innovation, Mount Kenya University, Thika, Kenya.
  • Rahmat R; Centre for Malaria Elimination, Mount Kenya University, Thika, Kenya.
  • Hasan I; Biological Sciences Department, Academy of Medical Sciences, Malawi University of Science and Technology, Thyolo, Malawi.
  • Siddik AB; Institute for Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh.
  • Afrad MH; Institute for Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh.
  • Rahman MZ; Institute for Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh.
  • Miller G; International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Walt DR; International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Ivers LC; Mass General Brigham Center for COVID Innovation, Boston, Massachusetts.
  • LaRocque RC; Mass General Brigham Center for COVID Innovation, Boston, Massachusetts.
  • Harris JB; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts.
  • Qadri F; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Am J Trop Med Hyg ; 107(4): 845-849, 2022 10 12.
Article in English | MEDLINE | ID: covidwho-2265832
ABSTRACT
Early detection of SARS-CoV-2 infection is crucial to prevent its spread. This study aimed to document test sensitivity/specificity, correlation with cycle threshold value from polymerase chain reaction (PCR), fitness-for-use in different populations and settings, and user perspectives that could inform large-scale implementation. In this study, we evaluated the performance of a rapid antigen detection test, BD Veritor, and compared this (and another rapid test, Standard Q) against reverse transcription PCR (RT-PCR) in terms of sensitivity and specificity in 130 symptomatic and 130 asymptomatic adults. In addition, we evaluated the suitability and ease of use of the BD Veritor test in a subsample of study participants (n = 42) and implementers (n = 5). At 95% confidence interval, the sensitivity of the BD Veritor and Standard Q test were 70% and 63% in symptomatic and 87% and 73% in asymptomatic individuals, respectively, regarding positive SARS-CoV-2 RT-PCR results. Overall, the BD Veritor test was 78% sensitive and 99.5% specific compared with RT-PCR irrespective of the cycle threshold. This warrants large field evaluation as well as use of the rapid antigen test for quick assessment of SARS-CoV-2 for containment of epidemics in the country.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Am J Trop Med Hyg Year: 2022 Document Type: Article Affiliation country: Ajtmh.22-0068

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Am J Trop Med Hyg Year: 2022 Document Type: Article Affiliation country: Ajtmh.22-0068