COVID 19 and Bullous Pemphigoid: a hypothesis for a causal link
Journal of Biological Regulators and Homeostatic Agents
; 36(2):19-25, 2022.
Article
in English
| Web of Science | ID: covidwho-1995262
ABSTRACT
Although onset/exacerbation of bullous Pemphigoid (BP) has been reported to occur frequently following exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the link, if any, between BP dermatoses and the viral infection remains obscure. Therefore, searching for possible molecular mechanisms, we hypothesise that molecular mimicry between BP antigens and the SARS-CoV-2 proteins might lead to autoimmune responses cross-reacting with the BP proteins, thus triggering the dermatosis pathologies. Using this research paradigm, we analyzed the Bullous Pemphigoid antigen 1 (BP230) and the SARS-CoV-2 proteome to share minimal immune determinants, i.e., pentapeptides. Results indicate a high level of molecular mimicry between BP230 and SARS-CoV-2, thus supporting the hypothesis of cross-reactivity as a possible major mechanism in the SARS-CoV-2-associated BP etiopathogenesis.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Journal of Biological Regulators and Homeostatic Agents
Year:
2022
Document Type:
Article
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