A 51-YEAR-OLD MAN WITH WEIGHT LOSS AND CARDIOGENIC SHOCK
Journal of General Internal Medicine
; 37:S381, 2022.
Article
in English
| EMBASE | ID: covidwho-1995664
ABSTRACT
CASE A 51-year-old man without significant past medical history presented to our hospital with dyspnea on exertion. SARS-CoV-2 was detected on routine occupational screening 2 months prior to admission. He subsequently reported a 100lb weight loss, during which time he experienced dysgeusia and ate primarily cereal, sandwiches, and potatoes and consumed nearly no fruits or vegetables. Three weeks prior to admission he developed postprandial nausea and vomiting and anorexia. A week later he developed progressive epigastric pain, lower extremity edema, and dyspnea while walking around the college campus where he worked as a security guard, and sought medical attention. He did not have fever, chills, night sweats, cough, orthopnea, paroxysmal nocturnal dyspnea, rash, or diarrhea. He had not seen a doctor in 20 years and took no medications. He did not drink alcohol, smoke cigarettes, or use illicit substances. Vital signs were T 36.6°F HR 104 BP 149/111 RR 20 and SpO2 97%. Physical examination revealed a cachectic man with bitemporal wasting, sunken orbits, poor dentition, and severe periodontal disease. JVP was 14cm of H2O at 45°. An S3 was present. The abdomen was tender to palpation in the mid epigastrium. The extremities were cool with 3+ pitting edema. Pancreatitis was diagnosed after discovery of markedly elevated lipase levels and peripancreatic fat stranding on abdominal CT. TTE showed biventricular systolic dysfunction with LVEF 15%. He developed cardiogenic shock complicated by oliguric renal failure, congestive hepatopathy and obtundation, requiring ICU transfer for diuresis and inotropic support. Further workup revealed deficiencies of thiamine, zinc, and vitamins A, C, and D. A regadenoson myocardial perfusion PET/CT showed no flow-limiting coronary artery disease, and workup for inflammatory, infectious, and toxic-metabolic causes of heart failure was unrevealing. While COVID myocarditis and multisystem inflammatory syndrome in adults (MIS-A) were considered, ultimately, a diagnosis of wet beriberi was made. After 5 months of aggressive nutritional supplementation via percutaneous gastrostomy tube and initiation of guideline-directed medical therapy, LVEF improved to 53% and weight increased by 35lbs. IMPACT/DISCUSSION:
Wet beriberi is a potentially underrecognized cause of dilated cardiomyopathy in resource-rich areas. Within 3 months, thiamine deficiency can cause high-output heart failure due to impaired myocardial energy metabolism and dysautonomia. Risk factors include alcohol use disorder, prolonged vomiting, and history of bariatric surgery.CONCLUSION:
The laboratory evaluation of non-ischemic dilated cardiomyopathy should include measurement of serum thiamine, carnitine, and selenium levels in select patients, alongside iron studies, ANA, screening for HIV, Chagas disease, and viral myocarditis, and genetic testing in patients with a suggestive family history. Empiric thiamine repletion should be considered in all critically ill patients with evidence of malnutrition.
alcohol; carnitine; endogenous compound; iron; regadenoson; retinol; selenium; thiamine; triacylglycerol lipase; water; zinc; abdomen; adult; alcoholism; anorexia; attention; autonomic dysfunction; bariatric surgery; beriberi; body weight loss; cachexia; cardiogenic shock; case report; cereal; Chagas disease; chill; cigarette; clinical article; college; complication; conference abstract; congestive cardiomyopathy; coronary artery disease; coronavirus disease 2019; coughing; critically ill patient; dentition; diagnosis; diarrhea; diet supplementation; diuresis; dysgeusia; dyspnea; edema; energy metabolism; epigastric pain; exertional dyspnea; family history; fever; fruit; gene expression; genetic screening; heart failure; heart left ventricle ejection fraction; heart muscle perfusion; high output heart failure; human; Human immunodeficiency virus; human tissue; inotropism; kidney failure; limb; liver disease; male; medical history; middle aged; myocarditis; nausea and vomiting; night sweat; nonhuman; oliguria; orbit; palpation; pancreatitis; paroxysmal nocturnal dyspnea; periodontal disease; positron emission tomography-computed tomography; potato; practice guideline; rash; risk factor; security personnel; Severe acute respiratory syndrome coronavirus 2; smoke; stomach tube; stupor; systemic inflammatory response syndrome; systolic dysfunction; vegetable; virus myocarditis; vital sign; vomiting; walking
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of General Internal Medicine
Year:
2022
Document Type:
Article
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