Evaluation of prognostic markers in patient infected with SARSCoV-2
Hepatology International
; 16:S495, 2022.
Article
in English
| EMBASE | ID: covidwho-1995894
ABSTRACT
Objectives:
Prognostic markers used to measure the disease progression and patient outcome regardless of treatment in COVID-19. We aim to analyze and evaluate the prognostic markers for early identification of severe patients. Materials andMethods:
During a 3-month period (November 2020 to January 2021), a total of 165 patients attending Sukraraj Tropical and Infectious Disease Hospital with laboratory-confirmed COVID-19 were enrolled and divided into non-severe and severe groups. The demographic data, underlying co-morbidities and laboratory findings were analyzed. Correlation, Regression analysis and ROC curve was performed to determine the risk factors and cut-off values for critically ill patients were speculated.Results:
Disease severity was significantly associated with age (r = 0.359, p<0.001), RBC (r = -0.163, p = 0.037), AEC (r = -0.300, p<0.001), ALC (r = -0.239, p<0.001), ANC (r = 0.228, p<0.001), NLR (r = 0.336, p<0.001), PLR (r = 0.286, p<0.001), glucose (r = 0.155, p = 0.046), urea (r = 0.282, p<0.001), creatinine (r = 0.194, p = 0.012), AST (r = 0.169, p = 0.030), ferritin (r = 0.359, p<0.001) and CRP. Whereas Increasing age (AOR = 3.611), positive CRP (AOR = 2.930), high ferritin (AOR = 2.754), decreased AEC (AOR = 3.415) was found to be independent risk factors for COVID-19 severity. Similarly, ROC (Receiver Operating Characteristics) curve analysis showed age (AUC = 0.724), NLR (AUC = 0.710), PLR (AUC = 0.678), ferritin (AUC = 0.735), AEC (AUC = 0.661) can be used to monitor the disease severity.Conclusion:
Our study revealed severe COVID-19 is associated with increased markers of innate immune response such as neutrophil count, NLR, CRP and serum ferritin;decreased markers of adaptive immune response such as lymphocyte and increased markers of major organ damage including AST, urea, and creatinine compared to COVID-19.
C reactive protein; creatinine; endogenous compound; ferritin; glucose; urea; adaptive immunity; adult; age; aspartate aminotransferase level; communicable disease; comorbidity; conference abstract; controlled study; coronavirus disease 2019; critically ill patient; demographics; female; ferritin blood level; human; human tissue; innate immunity; lymphocytosis; major clinical study; male; neutrophil count; neutrophil lymphocyte ratio; organ injury; receiver operating characteristic; risk factor; tropical disease
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Prognostic study
Language:
English
Journal:
Hepatology International
Year:
2022
Document Type:
Article
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