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Alteration in liver function following use of remdesivir in COVID-19 patients: A prospective study
Hepatology International ; 16:S302, 2022.
Article in English | EMBASE | ID: covidwho-1995904
ABSTRACT

Objectives:

Background:

COVID-19 infection has been affecting humans globally since December, 2019 and Remdesivir was first approved by FDA for treating severe COVID-19 pneumonia in July, 2020 though its hepatic safety has not been adequately studied. Remdesivir, a nucleotide analog prodrug, has been found to create derangement in liver function. However, COVID-19 infection itself has transient implications over liver enzymes.

Aims:

To evaluate the effect of Remdesivir on liver function in COVID-19 in-patients with normal liver function. Materials and

Methods:

This prospective study was conducted at Mediplus Hospital and Trauma Center from 1st September, 2020 to 31st May, 2021. Ethical approval was obtained and 107 PCR positive COVID-19 in-patients with normal liver function test (LFT) were included in the study. Liver enzymes ( alanine and aspartate transaminases and alkaline phosphatases) and serum bilirubin were sent after 72 h of initiation of the drug. Data was entered in Microsoft excel and result studied.

Results:

Out of 125 included patients, LFT became deranged in 39 (31.2%) patients. Among those 39 patients, 16 (41.0%) had isolated raised ALT, 9 (23.1%) had isolated raised AST and 14 (35.9%) had all three enzymes (AST, ALT and ALP) raised, while serum bilirubin was found to be raised in only 11 (28.2%) (Diagram1).

Conclusion:

Biochemical alteration in liver function has been noted in Covid-19 patients after the Remdesivir therapy. However, that effect could also be due to hepatic implications of Covid-19 infection itself and concomitant use of other drugs.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Hepatology International Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Hepatology International Year: 2022 Document Type: Article