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Microfluidic preparation of antimicrobial microparticles composed of l-lactide/1,3-dioxolane (co)polymers loaded with quercetin.
Kost, Bartlomiej; Kunicka-Styczynska, Alina; Plucinska, Aleksandra; Rajkowska, Katarzyna; Basko, Malgorzata; Brzezinski, Marek.
  • Kost B; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
  • Kunicka-Styczynska A; Department of Sugar Industry and Food Safety Management, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczanska 171/173, 90-924 Lodz, Poland.
  • Plucinska A; Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczanska 171/173, 90-924 Lodz, Poland.
  • Rajkowska K; Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczanska 171/173, 90-924 Lodz, Poland.
  • Basko M; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland. Electronic address: baskomeg@cbmm.lodz.pl.
  • Brzezinski M; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland. Electronic address: mbrzezin@cbmm.lodz.pl.
Food Chem ; 396: 133639, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-1996165
ABSTRACT
The resistance of microorganisms against commonly used antibiotics is becoming an increasingly important problem in the food and pharmaceutical industries. Therefore, the development of novel bactericidal agents, as well as the design of drug delivery systems based on materials composed of biocompatible and biodegradable building blocks, has attracted increasing attention. To address this challenge, microparticles composed of l-lactide homopolymer and l-lactide/1,3-dioxolane (co)polymers loaded with quercetin (Q) were fabricated by using a microfluidic technique. This method enables the preparation of homogeneous particles with sizes ranging from 60 to 80 µm, composed of degradable semicrystalline or amorphous (co)polyesters. The microencapsulation of Q in a (co)polymeric matrix enables prolonged release of the antimicrobial agent. The antibacterial properties of the obtained biocompatible microparticles are confirmed by the agar diffusion plate method for various bacterial strains. Therefore, Q-loaded microparticles can have important applications in food preservation as a novel antimicrobial system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyglycolic Acid / Lactic Acid Language: English Journal: Food Chem Year: 2022 Document Type: Article Affiliation country: J.foodchem.2022.133639

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyglycolic Acid / Lactic Acid Language: English Journal: Food Chem Year: 2022 Document Type: Article Affiliation country: J.foodchem.2022.133639