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Molecular mimicry, hyperactive immune system, and SARS-COV-2 are three prerequisites of the autoimmune disease triangle following COVID-19 infection.
Vahabi, Maedeh; Ghazanfari, Tooba; Sepehrnia, Saeed.
  • Vahabi M; Immunology Department, Immunoregulation Research Center, Shahed University, Tehran, Iran.
  • Ghazanfari T; Immunology Department, Immunoregulation Research Center, Shahed University, Tehran, Iran.
  • Sepehrnia S; Immunology Department, Immunoregulation Research Center, Shahed University, Tehran, Iran.
Int Immunopharmacol ; 112: 109183, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1996289
ABSTRACT
SARS-CoV-2 infection can produce a variety of clinical manifestations, which are either directly related to viral tissue damage or indirectly induced by the antiviral immune response. Molecular mimicry enables this virus to undermine self-tolerance in a host's immune system also immune system's attempts to eliminate SARS-COV-2 may trigger autoimmunity by hyper-activating the innate and adaptive immune systems. Auto immune diseases include Systemic lupus erythematosus, autoimmune thyroid diseases, Guillain-Barre syndrome, Immune thrombocytopenic purpura, and the detection of autoantibodies are the cues to the discovery of the potential of COVID-19 in inducing autoimmunity. As COVID-19 and autoimmune diseases share a common pathogenesis, autoimmune drugs may be an effective treatment option. Susceptible patients must be monitored for autoimmune symptoms after contracting CVID-19. In light of the SARS-COV-2 virus' ability to induce autoimmunity in susceptible patients, will the various COVID-19 vaccines that are the only way to end the pandemic induce autoimmunity?
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Purpura, Thrombocytopenic, Idiopathic / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2022 Document Type: Article Affiliation country: J.intimp.2022.109183

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Purpura, Thrombocytopenic, Idiopathic / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2022 Document Type: Article Affiliation country: J.intimp.2022.109183