The effect of SARS-CoV-2 mRNA vaccination on AMH concentrations in infertile women.
Reprod Biomed Online
; 45(4): 779-784, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-1996515
ABSTRACT
RESEARCH QUESTION Does SARS-CoV-2 mRNA vaccination affect the ovarian reserve of infertile women undergoing IVF? DESIGN:
This was a prospective observational study at a single university-affiliated IVF unit that included infertile women aged 18-44 years who were undergoing IVF/intracytoplasmic sperm injection between November 2020 and September 2021, had received two doses of SARS-CoV-2 mRNA vaccination and had undergone measurement of baseline anti-Müllerian hormone (AMH) concentration within the 12 months preceding their recruitment. AMH concentrations before and after vaccination were evaluated and compared.RESULTS:
Overall, 31 women were included in the study. The median AMH concentrations before and after COVID-19 vaccine were comparable (1.7 versus 1.6 g/ml, respectively, Pâ¯=â¯0.96). No correlation was found between the participant's anti-COVID-19 antibody titre and the change in AMH concentration.CONCLUSIONS:
SARS-CoV-2 mRNA vaccination does not adversely affect ovarian reserve, as shown by comparing serum AMH concentrations before and after vaccination. These findings may serve as a counselling tool for clinicians to reassure women undergoing fertility treatment that SARS-CoV-2 mRNA vaccination is safe.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ovarian Reserve
/
COVID-19
/
Infertility, Female
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Female
/
Humans
Language:
English
Journal:
Reprod Biomed Online
Journal subject:
Reproductive Medicine
Year:
2022
Document Type:
Article
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