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The Mutual Relationship among Cardiovascular Diseases and COVID-19: Focus on Micronutrients Imbalance.
Severino, Paolo; D'Amato, Andrea; Prosperi, Silvia; Myftari, Vincenzo; Labbro Francia, Aurora; Önkaya, Merve; Notari, Claudia; Papisca, Ilaria; Canuti, Elena Sofia; Yarden Revivo, Mia; Birtolo, Lucia Ilaria; Celli, Paola; Galardo, Gioacchino; Maestrini, Viviana; d'Ettorre, Gabriella; Mancone, Massimo; Fedele, Francesco.
  • Severino P; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • D'Amato A; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Prosperi S; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Myftari V; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Labbro Francia A; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Önkaya M; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Notari C; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Papisca I; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Canuti ES; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Yarden Revivo M; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Birtolo LI; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Celli P; Anesthesiology and Intensive Care Unit, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
  • Galardo G; Medical Emergency Unit, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy.
  • Maestrini V; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Mancone M; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  • Fedele F; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Nutrients ; 14(16)2022 Aug 21.
Article in English | MEDLINE | ID: covidwho-1997730
ABSTRACT
Micronutrients are ions and vitamins humbly required by the human body. They play a main role in several physiological mechanisms and their imbalance is strongly associated with potentially-fatal complications. Micronutrient imbalance is associated with many cardiovascular diseases, such as arrythmias, heart failure, and ischemic heart disease. It has been also observed in coronavirus disease 2019 (COVID-19), particularly in most severe patients. The relationship between cardiovascular diseases and COVID-19 is mutual the latter triggers cardiovascular disease onset and worsening while patients with previous cardiovascular disease may develop a more severe form of COVID-19. In addition to the well-known pathophysiological mechanisms binding COVID-19 and cardiovascular diseases together, increasing importance is being given to the impact of micronutrient alterations, often present during COVID-19 and able to affect the balance responsible for a good functioning of the cardiovascular system. In particular, hypokalemia, hypomagnesemia, hyponatremia, and hypocalcemia are strongly associated with worse outcome, while vitamin A and D deficiency are associated with thromboembolic events in COVID-19. Thus, considering how frequent the cardiovascular involvement is in patients with COVID-19, and how it majorly affects their prognosis, this manuscript provides a comprehensive review on the role of micronutrient imbalance in the interconnection between COVID-19 and cardiovascular diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Trace Elements / Cardiovascular Diseases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14163439

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Trace Elements / Cardiovascular Diseases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14163439