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Experimental Infection of Brazilian Free-Tailed Bats (Tadarida brasiliensis) with Two Strains of SARS-CoV-2.
Bosco-Lauth, Angela M; Porter, Stephanie M; Fox, Karen A; Wood, Mary E; Neubaum, Daniel; Quilici, Marissa.
  • Bosco-Lauth AM; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
  • Porter SM; U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, Fort Collins, CO 80523, USA.
  • Fox KA; Colorado Parks and Wildlife, Fort Collins, CO 80523, USA.
  • Wood ME; Colorado Parks and Wildlife, Fort Collins, CO 80523, USA.
  • Neubaum D; Colorado Parks and Wildlife, Fort Collins, CO 80523, USA.
  • Quilici M; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Viruses ; 14(8)2022 08 18.
Article in English | MEDLINE | ID: covidwho-1997800
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presumed to have originated from wildlife and shares homology with other bat coronaviruses. Determining the susceptibility of North American bat species to SARS-CoV-2 is of utmost importance for making decisions regarding wildlife management, public health, and conservation. In this study, Brazilian free-tailed bats (Tadarida brasiliensis) were experimentally infected with two strains of SARS-CoV-2 (parental WA01 and Delta variant), evaluated for clinical disease, sampled for viral shedding and antibody production, and analyzed for pathology. None of the bats (n = 18) developed clinical disease associated with infection, shed infectious virus, or developed histopathological lesions associated with SARS-CoV-2 infection. All bats had low levels of viral RNA in oral swabs, six bats had low levels of viral RNA present in the lungs during acute infection, and one of the four bats that were maintained until 28 days post-infection developed a neutralizing antibody response. These findings suggest that Brazilian free-tailed bats are permissive to infection by SARS-CoV-2, but they are unlikely to contribute to environmental maintenance or transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Animals / Humans Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14081809

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Variants Limits: Animals / Humans Country/Region as subject: South America / Brazil Language: English Year: 2022 Document Type: Article Affiliation country: V14081809