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DETERMINATION OF AURINTRICARBOXYLIC ACID (A VIRAL INHIBITOR) USING MIXED MICELLAR CLOUD POINT EXTRACTION PROCEDURES
International Journal of Applied Pharmaceutics ; 14(4):279-281, 2022.
Article in English | EMBASE | ID: covidwho-1998137
ABSTRACT

Objective:

Development of micelle mediated cloud point extraction (CPE) and preconcentration of aurintricarboxylic acid (ATCA) (a viral inhibitor).

Methods:

The method is based on the ion-pair formation between ATCA and a cationic surfactant tetrabutylammonium bromide (TBAB), which is extracted into the Triton X-114 (TX-114, a non-ionic surfactant) at a pH 4.4. The effect of different important parameters like pH, the concentration of surfactants (TX-114 and TBAB), salt, temperature, and time for the extraction of ATCA was optimized.

Results:

Extraction efficiency of 90.28 % for CPE of ATCA was obtained using mixed micelles of TX-114 and TBAB. The linear range and limits of detection for ATCA was found to be 8.44-84.47 µg ml-1 and 8.14 ng ml-1, respectively.

Conclusion:

The suggested CPE method has been applied to the determination of ATCA in aqueous solutions.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: International Journal of Applied Pharmaceutics Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: International Journal of Applied Pharmaceutics Year: 2022 Document Type: Article