DETERMINATION OF AURINTRICARBOXYLIC ACID (A VIRAL INHIBITOR) USING MIXED MICELLAR CLOUD POINT EXTRACTION PROCEDURES
International Journal of Applied Pharmaceutics
; 14(4):279-281, 2022.
Article
in English
| EMBASE | ID: covidwho-1998137
ABSTRACT
Objective:
Development of micelle mediated cloud point extraction (CPE) and preconcentration of aurintricarboxylic acid (ATCA) (a viral inhibitor).Methods:
The method is based on the ion-pair formation between ATCA and a cationic surfactant tetrabutylammonium bromide (TBAB), which is extracted into the Triton X-114 (TX-114, a non-ionic surfactant) at a pH 4.4. The effect of different important parameters like pH, the concentration of surfactants (TX-114 and TBAB), salt, temperature, and time for the extraction of ATCA was optimized.Results:
Extraction efficiency of 90.28 % for CPE of ATCA was obtained using mixed micelles of TX-114 and TBAB. The linear range and limits of detection for ATCA was found to be 8.44-84.47 µg ml-1 and 8.14 ng ml-1, respectively.Conclusion:
The suggested CPE method has been applied to the determination of ATCA in aqueous solutions.
centrifuge; ultraviolet spectrophotometer; antivirus agent; aurintricarboxylic acid; cationic surfactant; surfactant; tetrabutylammonium; triton x 114; aqueous solution; article; centrifugation; micelle; molecular docking; nonhuman; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; spectrophotometry
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
International Journal of Applied Pharmaceutics
Year:
2022
Document Type:
Article
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