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Innate immunity to SARS-CoV-2 infection: a review.
Silva, Marcos Jessé Abrahão; Rodrigues, Yan Corrêa; Lima, Karla Valéria Batista; Lima, Luana Nepomuceno Gondim Costa.
  • Silva MJA; Graduate Program in Epidemiology and Health Surveillance (PPGEVS) of the Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
  • Rodrigues YC; Bacteriology and Mycology Section of the Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
  • Lima KVB; Bacteriology and Mycology Section of the Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
  • Lima LNGC; Bacteriology and Mycology Section of the Evandro Chagas Institute (IEC), Ananindeua, Pará, Brazil.
Epidemiol Infect ; 150: e142, 2022 07 18.
Article in English | MEDLINE | ID: covidwho-2000833
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified in China, has spread around the world causing high morbidity and mortality, which is due to factors such as the subversion of the immune response. The aims of the study are to summarise and present the immunopathological relationship of COVID-19 with innate immunity. This is a systematic review conducted by the National Library of Medicine - National Institutes of Health, USA (PUBMED), Latin American and Caribbean Literature on Health Sciences (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scientific Electronic Library Online (SCIELO) databases with clinical trials, in vitro assays, case-controls, cohort studies, systematic reviews and meta-analyses between February 2020 and July 2021. The version 2 of the Cochrane risk-of-bias tool for RCTs (RoB 2), Joana Briggs Institute (JBI) Critical Appraisal (for the review articles) and the Risk of Bias in Non-randomised Studies of Interventions (ROBINS-I) tools were used to evaluate the quality and the risk of bias of the studies included in this review. The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. Then, in addition to interacting as a bridge for adaptive immunity, the innate immune response plays an essential role in primary defense and is one of the starting points for immune evasion by SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Country/Region as subject: North America Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2022 Document Type: Article Affiliation country: S095026882200125X

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Country/Region as subject: North America Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2022 Document Type: Article Affiliation country: S095026882200125X